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Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies.
The Journal of Nutritional Biochemistry ( IF 5.6 ) Pub Date : 2020-07-30 , DOI: 10.1016/j.jnutbio.2020.108466
Emily J Prpa 1 , Christopher P Corpe 1 , Ben Atkinson 1 , Brittany Blackstone 1 , Elizabeth S Leftley 1 , Priya Parekh 1 , Mark Philo 2 , Paul A Kroon 2 , Wendy L Hall 1
Affiliation  

Background

Previous research demonstrated that a high dose of phlorizin-rich apple extract (AE) can markedly inhibit early-phase postprandial glycemia, but efficacy of lower doses of the AE is unclear.

Objective

To determine whether lower AE doses reduce early-phase postprandial glycemia in healthy adults and investigate mechanisms.

Design

In a randomized, controlled, double-blinded, cross-over acute trial, drinks containing 1.8 g (HIGH), 1.35 g (MED), 0.9 g (LOW), or 0 g (CON) of a phlorizin-rich AE were consumed before 75 g starch/sucrose meal. Postprandial blood glucose, insulin, C-peptide, glucose-dependent insulinotropic polypeptide (GIP) and polyphenol metabolites concentrations were measured 0–240 min, acetaminophen concentrations to assess gastric emptying rate, and 24 h urinary glucose excretion. Effects of AE on intestinal glucose transport were investigated in Caco-2/TC7 cells.

Results

AE significantly reduced plasma glucose iAUC 0–30 min at all doses: mean differences (95% CI) relative to CON were −15.6 (−23.3, −7.9), −11.3 (−19.6, −3.0) and −8.99 (−17.3, −0.7) mmol/L per minute for HIGH, MEDIUM and LOW respectively, delayed Tmax (HIGH, MEDIUM and LOW 45 min vs. CON 30 min), but did not lower Cmax. Similar dose-dependent treatment effects were observed for insulin, C-peptide, and GIP. Gastric emptying rates and urinary glucose excretion did not differ. Serum phloretin, quercetin and epicatechin metabolites were detected postprandially. A HIGH physiological AE dose equivalent decreased total glucose uptake by 48% in Caco-2/TC7 cells.

Conclusions

Phlorizin-rich AE, even at a low dose, can slightly delay early-phase glycemia without affecting peak and total glycemic response.



中文翻译:

富含苹果多酚的饮料在高糖餐后剂量依赖性地降低餐后早期葡萄糖浓度:在健康成人和体外研究中的一项随机对照试验。

背景

先前的研究表明,高剂量的富含Phlorizin的苹果提取物(AE)可以显着抑制早期餐后血糖,但低剂量AE的疗效尚不清楚。

目的

为了确定较低的AE剂量是否可以降低健康成人的早期餐后血糖并研究其机制。

设计

在一项随机,对照,双盲,交叉交叉急性试验中,饮用了含有1.8 g(HIGH),1.35 g(MED),0.9 g(LOW)或0 g(CON)的富含Phrizrizin的AE饮料在75克淀粉/蔗糖粉之前。在0至240分钟内测量餐后血糖,胰岛素,C肽,葡萄糖依赖性促胰岛素多肽(GIP)和多酚代谢产物的浓度,对乙酰氨基酚的浓度以评估胃排空率和24小时尿葡萄糖排泄。在Caco-2 / TC7细胞中研究了AE对肠道葡萄糖转运的影响。

结果

AE在所有剂量下均显着降低了iAUC 0-30分钟的血浆葡萄糖:相对于CON的平均差异(95%CI)为-15.6(-23.3,-7.9),-11.3(-19.6,-3.0)和-8.99(-17.3)高,中和低分别为-0.7)mmol / L /分钟,延迟了T max(高,中和低45分钟,CON为30分钟),但并未降低C max。对于胰岛素,C肽和GIP观察到相似的剂量依赖性治疗效果。胃排空率和尿葡萄糖排泄没有差异。餐后检测到血清促肾上腺皮质激素,槲皮素和表儿茶素代谢产物。在Caco-2 / TC7细胞中,较高的生理AE剂量当量可使总葡萄糖摄取减少48%。

结论

富含草甘膦的AE,即使是低剂量的AE,也可以稍微延迟早期血糖,而不会影响峰值和总血糖反应。

更新日期:2020-09-18
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