Background

The impact of aerobic training on pulmonary function by modulating gene expression of estrogen receptor-alpha (ERα), sex hormones and 25-hydroxy vitamin D (Vit D) in postmenopausal women (PMW) with Vit D deficiency is uncertain.

Objective

The purpose of this study was to examine the effect of 12 weeks of moderate-intensity aerobic training on pulmonary function, ERα gene expression, serum levels of sex hormones and Vit D in PMW with Vit D deficiency.

Methods

Twenty-nine sedentary PMW with Vit D deficiency (aged 45-65 yrs) were randomized to exercise (EX, n = 15) and control (C, n = 14) groups. The EX group performed moderate-intensity aerobic training for 12 weeks (50-60 min/day, 3 days/week at 65-70% of maximal heart rate reserve), but the C group participated in no intervention and maintain their normal lifestyle during 12 weeks. The pulmonary function parameters, ERα gene expression, serum levels of sex hormones and Vit D were measured at baseline and week-12.

Results

After 12 weeks of aerobic exercise intervention, the increase in lymphocyte ERα gene expression (p = 0.005, estimate of effect size/Eta = 32.8%) and serum Vit D (p = 0.001, Eta = 54.7%) were significantly higher in the EX group compared to the C group, whereas pulmonary function parameters and sex hormones (17β-estradiol and progesterone) were not significantly different (P > 0.05).

Conclusions

The results suggested that 12 weeks of moderate-intensity aerobic training increased lymphocyte ERα gene expression as well as serum Vit D in sedentary PMW with Vit D deficiency although pulmonary function was not improved.

中文翻译：

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中等强度有氧训练对维生素 D 缺乏症绝经后妇女肺功能和雌激素受体-α 基因的影响：一项随机对照试验。

背景

有氧训练通过调节雌激素受体-α ( ERα)、性激素和 25-羟基维生素 D (Vit D) 的基因表达对维生素 D 缺乏的绝经后妇女 (PMW) 的肺功能的影响尚不确定。

客观的

本研究的目的是检查 12 周中等强度有氧训练对肺功能、ERα 基因表达、血清性激素水平和维生素 D 缺乏症 PMW 的影响。

方法

29 名患有维生素 D 缺乏症的久坐 PMW（45-65 岁）被随机分配到运动组（EX，n = 15）和对照组（C，n = 14）。EX组进行12周中等强度有氧训练（50-60分钟/天，3天/周，最大心率储备的65-70%），但C组不参与干预，期间保持正常生活方式。 12 周。在基线和第 12 周测量肺功能参数、ERα 基因表达、性激素和维生素 D 的血清水平。

结果

有氧运动干预12周后，EX中淋巴细胞ERα基因表达（p = 0.005，效应量估计值/Eta = 32.8%）和血清Vit D（p = 0.001，Eta = 54.7%）的增加显着升高组与C组相比，肺功能参数和性激素（17β-雌二醇和孕酮）无显着差异（P > 0.05）。

结论

结果表明，12 周中等强度的有氧训练增加了淋巴细胞 ERα 基因表达以及维生素 D 缺乏的久坐 PMW 中的血清维生素 D，尽管肺功能没有改善。