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The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds.
Neuroscience Letters ( IF 2.5 ) Pub Date : 2020-07-30 , DOI: 10.1016/j.neulet.2020.135282
Chang Cao 1 , Elizabeth R Gilbert 1 , Mark A Cline 1
Affiliation  

Beta-melanocyte-stimulating hormone (β-MSH), when centrally injected, induces anorexigenic effects in rodents and chickens but its mechanism remains unclear. Thus, the primary goal of this research was to elucidate the hypothalamic mechanism using chickens. Intracerebroventricular injection of 0.3, 1.0 and 3.0 nmol of β-MSH decreased food intake for 540 min. Expression of hypothalamic mRNAs were affected by β-MSH injection, including corticotrophin-releasing factor (CRF) and its receptor subtype 1 (CRFR1), mesotocin (MT) and its receptor (MTR), pro-opiomelanocortin, cocaine- and amphetamine-regulated transcript (CART), growth hormone secretagogue receptor (GHSR) and neuropeptide Y (NPY) receptor subtype 5 (NPYR5). Within the arcuate nucleus, expressions of NPY, agouti-related peptide, MT and MTR were increased by β-MSH injection. β-MSH-treated chicks had more CRF, CRFR1, CRF receptor subtype 2, GHSR, NPY receptor subtype 1 (NPYR1) and NPYR5 mRNA but lower levels of CART and ghrelin, in the paraventricular nucleus. Greater amounts of mRNA for MTR, GHSR, NPYR1 and NPYR5 and less CRF expression were observed in the ventromedial hypothalamus. In conclusion, central injection of β-MSH potently reduced food intake and was associated with changes in mRNA expression of some anorexigenic factors in a hypothalamic nucleus-specific manner.



中文翻译:

β-黑素细胞刺激激素的厌食作用涉及家禽中促肾上腺皮质激素释放因子和间质素。

集中注射β-黑素细胞刺激激素(β-MSH)可以在啮齿动物和鸡中引起厌食作用,但其机制尚不清楚。因此,这项研究的主要目的是阐明使用鸡的下丘脑机制。脑室内注射0.3、1.0和3.0 nmol的β-MSH会减少540分钟的食物摄入。下丘脑mRNA的表达受β-MSH注射的影响,包括促肾上腺皮质激素释放因子(CRF)及其受体亚型1(CRFR1),中膜毒素(MT)及其受体(MTR),前阿魏黑素皮质素,可卡因和苯丙胺调节转录本(CART),生长激素促分泌素受体(GHSR)和神经肽Y(NPY)受体5亚型(NPYR5)。β-MSH注射可增加弓形核内NPY,刺足相关肽,MT和MTR的表达。经β-MSH处理的雏鸡的心室旁核中CRF,CRFR1,CRF受体亚型2,GHSR,NPY受体亚型1(NPYR1)和NPYR5 mRNA较多,但CART和生长素释放肽水平较低。在腹膜下丘脑中观察到大量的MTR,GHSR,NPYR1和NPYR5 mRNA和较少的CRF表达。总之,集中注射β-MSH可以有效地减少食物摄入,并以下丘脑核特异的方式与某些厌食因子的mRNA表达变化相关。

更新日期:2020-08-11
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