The aim of this study was to investigate the effect of PEGlated nanoliposome of pistachio unsaturated oils (PEGNLPUOs) to attenuate the inflammatory response in the EAE model by modulating of NFKB and oxidative stress signaling pathway. Real-time PCR demonstrated that the administration of 10%v/v PEGNLPUOs significantly decreased the expression level of AKT1, MAPK, and NFKB genes from NFKB signaling pathway and MGST1, NOS2, and HO-1 genes from oxidative stress signaling pathway. This study showed that the administration of pistachio oil and PEGNLPUOs at a concentration of 10%v/v decreased the number and percentage of Th1(CD4+) and increased Th2(CD8+) cells.

中文翻译：

---

通过开心果油的聚乙二醇化纳米脂质体减弱 EAE 模型中的炎症反应

本研究的目的是研究开心果不饱和油的聚乙二醇化纳米脂质体 (PEGNLPUOs) 通过调节 NFKB 和氧化应激信号通路来减弱 EAE 模型中炎症反应的作用。实时 PCR 表明，10%v/v PEGNLPUOs 的给药显着降低了来自 NFKB 信号通路的 AKT1、MAPK 和 NFKB 基因以及来自氧化应激信号通路的 MGST1、NOS2 和 HO-1 基因的表达水平。该研究表明，10%v/v 浓度的开心果油和 PEGNLPUOs 的给药降低了 Th1(CD4+) 的数量和百分比，并增加了 Th2(CD8+) 细胞。