This systematic review summarizes the evidence on the earliest patients with COVID-19-HIV co-infection. We searched PubMed, Scopus, Web of Science, Embase, preprint databases, and Google Scholar from December 01, 2019, to June 1, 2020. From an initial 547 publications and 75 reports, 25 studies provided specific information on COVID-19 patients living with HIV. Studies described 252 patients, 80.9% were male, the mean age was 52.7 years, and 98% were on antiretroviral treatment (ART). Co-morbidities in addition to HIV and COVID-19 (multimorbidity) included hypertension (39.3%), obesity or hyperlipidemia (19.3%), chronic obstructive pulmonary disease (18.0%), and diabetes (17.2%). Two-thirds (66.5%) had mild to moderate symptoms, the most common being fever (74.0%) and cough (58.3%). Among patients who died, the majority (90.5%) were over 50 years old, male (85.7%), and had multimorbidity (64.3%). Our findings highlight the importance of identifying co-infections, addressing co-morbidities, and ensuring a secure supply of ART for PLHIV during the COVID-19 pandemic.

本系统评价总结了最早的 COVID-19-HIV 合并感染患者的证据。从 2019 年 12 月 1 日到 2020 年 6 月 1 日，我们搜索了 PubMed、Scopus、Web of Science、Embase、预印本数据库和 Google Scholar。从最初的 547 篇出版物和 75 篇报告中，25 项研究提供了有关 COVID-19 患者生活的具体信息与艾滋病毒。研究描述了 252 名患者，80.9% 为男性，平均年龄为 52.7 岁，98% 接受抗逆转录病毒治疗 (ART)。除 HIV 和 COVID-19 外的合并症（多发病）包括高血压（39.3%）、肥胖或高脂血症（19.3%）、慢性阻塞性肺病（18.0%）和糖尿病（17.2%）。三分之二（66.5%）有轻度至中度症状，最常见的是发烧（74.0%）和咳嗽（58.3%）。在死亡的患者中，大多数（90. 5%) 年龄超过 50 岁，男性 (85.7%)，患有多种疾病 (64.3%)。我们的研究结果强调了在 COVID-19 大流行期间识别合并感染、解决合并症和确保为 PLHIV 安全供应 ART 的重要性。