The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.

中文翻译：

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2-取代的苯并咪唑在靶向癌症治疗中的多功能机制

这篇综述的目的是概述2-取代的苯并咪唑衍生物的各种抗癌活性。这篇综述提供了苯并咪唑作为抗癌剂的各种作用机制与细胞核周围的取代模式之间的相关性。已发现在N-1，C-2，C-5和C-6位置的连接基团和取代是抗癌活性的最主要因素。这将有助于进一步设计，以提供基于2取代的苯并咪唑类化合物的更具选择性，有效和多目标的抗癌药。