Tumor cells can die via immunogenic cell death pathway, in which damage-associated molecular pattern molecules (DAMPs) are released from the cells. These molecules activate cells involved in the immune response. Both innate and adaptive immune response can be activated, causing a destruction of the remaining infected cells. Activation of immune response is also an important component of tumor treatment with electrochemotherapy (ECT) and irreversible electroporation (IRE). We thus explored, if and when specific DAMPs are released as a consequence of electroporation in vitro.

中文翻译：

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体外细胞电穿孔引起的损伤相关分子模式分子的分析。

肿瘤细胞可以通过免疫原性细胞死亡途径死亡，在该途径中，损伤相关分子模式分子 (DAMP) 从细胞中释放出来。这些分子激活参与免疫反应的细胞。先天性和适应性免疫反应都可以被激活，从而破坏剩余的受感染细胞。免疫反应的激活也是电化学疗法 (ECT) 和不可逆电穿孔 (IRE) 治疗肿瘤的重要组成部分。因此，我们探讨了体外电穿孔是否以及何时释放特定的 DAMP 。