Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors and cytokines to integrate with and trigger protein signaling in the germ and embryo intracellular milieu. Src-homology-2-containing phosphotyrosine phosphatase (SHP2) is a ubiquitously expressed, multifunctional protein that plays a central role in the signaling pathways involved in growth factor receptors, cytokine receptors, integrins, and G protein-coupled receptors. Over recent decades, researchers have recapitulated the protein signaling networks that influence gamete progenitor specification as well as gamete differentiation and maturation. SHP2 plays an indispensable role in cellular growth, survival, proliferation, differentiation, and migration, as well as the basic events in gametogenesis and early embryo development. SHP2, a classic cytosolic protein and a key regulator of signal transduction, displays unconventional nuclear expression in the genital organs. Several observations provided shreds of evidence that this behavior is essential for fertility. The growth factor and cytokine-dependent roles of SHP2 and its nuclear/cytoplasmic presence during gamete maturation, early embryonic development and embryo implantation are fascinating and complex subjects. This review is intended to summarize the previous and recent knowledge about the SHP2 functions in gametogenesis and early embryo development.

中文翻译：

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生长因子和细胞因子；了解酪氨酸磷酸酶SHP2在配子发生和早期胚胎发育中的作用。

生长因子和细胞因子在生殖细胞发育，配子成熟和早期胚胎发育中具有至关重要的作用。存在用于生长因子和细胞因子的细胞表面受体，以与细菌和胚胎细胞内环境整合并触发蛋白质信号传导。包含Src同源2的磷酸酪氨酸磷酸酶（SHP2）是一种普遍表达的多功能蛋白，在涉及生长因子受体，细胞因子受体，整联蛋白和G蛋白偶联受体的信号传导途径中起着核心作用。在最近的几十年中，研究人员概述了影响配子祖细胞规格以及配子分化和成熟的蛋白质信号网络。SHP2在细胞生长，存活，增殖，分化和迁移中起着不可或缺的作用，以及配子发生和早期胚胎发育中的基本事件。SHP2是一种经典的胞质蛋白，是信号转导的关键调节因子，在生殖器官中显示出非常规的核表达。几项观察提供了一些证据，证明这种行为对生育至关重要。SHP2的生长因子和细胞因子依赖性作用及其在配子成熟，早期胚胎发育和胚胎植入过程中的核/胞质存在是令人着迷且复杂的主题。这篇综述旨在总结关于SHP2在配子发生和早期胚胎发育中功能的先前知识和最新知识。在生殖器官中显示出非常规的核表达。几项观察提供了一些证据，证明这种行为对生育至关重要。SHP2的生长因子和细胞因子依赖性作用及其在配子成熟，早期胚胎发育和胚胎植入过程中的核/胞质存在是令人着迷且复杂的主题。这篇综述旨在总结关于SHP2在配子发生和早期胚胎发育中功能的先前知识和最新知识。在生殖器官中显示出非常规的核表达。几项观察提供了一些证据，证明这种行为对生育至关重要。SHP2的生长因子和细胞因子依赖性作用及其在配子成熟，早期胚胎发育和胚胎植入过程中的核/胞质存在是令人着迷且复杂的主题。这篇综述旨在总结关于SHP2在配子发生和早期胚胎发育中功能的先前知识和最新知识。