Wnt signaling is well-known to play major roles in the hematopoietic system, from embryogenesis to aging and disease. In addition to the main β-catenin-dependent pathway, it is now clear that Wnt5a and the structurally related Wnt5b are essential for hematopoiesis, bone marrow colonization and the final steps of hematopoietic stem cell (HSC) maturation via β-catenin-independent signaling. Wnt5a and Wnt5b ligands prevent hematopoietic exhaustion (by maintaining quiescent, long-term HSCs), induce the proliferation of progenitors, and guide myeloid development, in addition to being involved in the development of aging-related alterations. The aim of this review is to summarize the current knowledge on these roles of Wnt5a and Wn5b signaling in the hematopoietic field.

中文翻译：

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终身造血过程中的Wnt-5A / B信号传导。

众所周知，Wnt信号传导在造血系统中起着重要作用，从胚胎发生到衰老和疾病。除了主要的β-catenin依赖性途径外，现在清楚的是，Wnt5a和与结构相关的Wnt5b对于造血功能，骨髓定植以及通过β-catenin独立信号传导的造血干细胞（HSC）成熟的最终步骤至关重要。Wnt5a和Wnt5b配体除了参与衰老相关变化的发生，还可以防止造血功能衰竭（通过维持静止的长期HSC），诱导祖细胞的增殖并指导骨髓的发育。这篇综述的目的是总结关于Wnt5a和Wn5b信号在造血领域中这些作用的当前知识。