A series of new 1,2,4‐triazole‐3‐thiones were synthesized by calm, benign, no risk, eco‐friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4‐triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4‐triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X‐ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4‐triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

中文翻译：

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纳米镍[1,2,4]-三唑-3-硫酮配合物：设计，声化学合成和抗菌评估

通过镇定，良性，无风险，生态友好和高效节能的顺序反应方法（如研磨和超声）合成了一系列新的1,2,4-三唑-3-硫酮。此外，按照常规方法制备了1,2,4-三唑并进行了比较研究。合成的1,2,4-三唑与Ni（II）络合，制得平均粒径从55到100 nm（使用扫描电子显微镜技术）变化的纳米颗粒复合物（NPC），通过美国和常规技术均具有良好的收率。使用X射线衍射技术和光谱分析技术来确定合成NPC的方形平面几何形状。研究了所制备的1,2,4-三唑及其镍配合物的抗菌活性，从而评价了高活性的配合物代替了它们的三唑。