当前位置: X-MOL 学术Stem Cells Transl. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives.
STEM CELLS Translational Medicine ( IF 6 ) Pub Date : 2020-07-29 , DOI: 10.1002/sctm.20-0247
Selami Demirci 1 , Alexis Leonard 1 , John F Tisdale 1
Affiliation  

The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) is an active and promising area of research; however, generating engraftable HSCs remains a major obstacle. Ex vivo HSC derivation from renewable sources such as iPSCs offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields tremendous therapeutic potential for malignant and nonmalignant hematological disorders. Although initial attempts mostly recapitulated yolk sac primitive/definitive hematopoiesis with inability to engraft, recent advances suggest the feasibility of engraftable HSC derivation from iPSCs utilizing ectopic transcription factor expression. Strategic development for de novo HSC generation includes further investigations of HSC ontogeny, and elucidation of critical signaling pathways, epigenetic modulations, HSC and iPSC microenvironment, and cell‐cell interactions that contribute to stem cell biology and function.

中文翻译:

来自多能干细胞的造血干细胞:临床潜力、挑战和未来前景。

从诱导多能干细胞 (iPSC) 生成造血干细胞 (HSC) 是一个活跃且有前景的研究领域。然而,产生可移植的 HSC 仍然是一个主要障碍。来自 iPSC 等可再生资源的离体 HSC 为研究发育性造血、疾病建模和药物发现提供了一种实验工具,并为恶性和非恶性血液病提供了巨大的治疗潜力。尽管最初的尝试主要是概括了无法移植的卵黄囊原始/确定性造血功能,但最近的进展表明利用异位转录因子表达从 iPSC 衍生可移植 HSC 的可行性。从头 HSC 生成的战略发展包括对 HSC 个体发育的进一步研究,
更新日期:2020-07-29
down
wechat
bug