Interaction polymer chromatography (IPC) is an umbrella term covering a large variety of primarily enthalpically-dominated macromolecular separation methods. These include temperature-gradient interaction chromatography, interactive gradient polymer elution chromatography (GPEC), barrier methods, etc. Also included are methods such as liquid chromatography at the critical conditions and GPEC in traditional precipitation-redissolution mode. IPC techniques are employed to determine the chemical composition distribution of copolymers, to separate multicomponent polymeric samples according to their chemical constituents, to determine the tacticity and end-group distribution of polymers, and to determine the chemical composition and molar mass distributions of select blocks in block copolymers. These are all properties which greatly affect the processing and end-use behavior of macromolecules. While extremely powerful, IPC methods are rarely employed outside academic and select industrial laboratories. This is generally because most published methods are “bespoke” ones, applicable only to the particular polymer being examined; as such, potential practitioners are faced with a lack of inductive information regarding how to develop IPC separations in non-empirical fashion. The aim of the present review is to distill from the literature and the author's experience the necessary fundamental macromolecular and chromatographic information so that those interested in doing so may develop IPC methods for their particular analytes of interest, regardless of what these analytes may be, with as little trial-and-error as possible. While much remains to be determined in this area, especially, for most techniques, as regards the role of temperature and how to fine-tune this critical parameter, and while a need for IPC columns designed specifically for large-molecule separations remains apparent, it is hoped that the present review will help place IPC methods in the hands of a more general, yet simultaneously more applied audience.

相互作用聚合物色谱法（IPC）是一个概括性术语，涵盖了许多主要由焓主导的大分子分离方法。这些方法包括温度梯度相互作用色谱法，相互作用梯度聚合物洗脱色谱法（GPEC），阻隔法等。还包括在临界条件下的液相色谱法和传统沉淀-溶解模式下的GPEC等方法。IPC技术用于确定共聚物的化学组成分布，根据其化学成分分离多组分聚合物样品，确定聚合物的立构规整度和端基分布，以及确定某些嵌段的化学组成和摩尔质量分布。嵌段共聚物。这些都是极大地影响大分子的加工和最终使用行为的特性。IPC方法虽然功能强大，但很少在学术机构和选定的工业实验室之外使用。通常是因为大多数公开的方法都是“定制”方法，仅适用于要检查的特定聚合物；因此，潜在的从业者面临着缺乏关于如何以非经验方式发展IPC分离的归纳信息。本综述的目的是从文献和作者的经验中提炼出必要的基本大分子和色谱信息，以便对此感兴趣的人可以针对其感兴趣的特定分析物开发IPC方法，而不论这些分析物是什么。尽可能少的反复试验。