Background and purpose: Botulinum toxin (BoNT) is a commonly used agent in the treatment of stroke-related spasticity. Sleep disorders can often be seen as a comorbidity or complication in stroke patients. Based on the data that spasticity is associated with sleep disorders, in this study, we aimed to evaluate whether sleep quality has changed in patients with stroke treated with BoNT. Methods: Thirty five (17 female / 18 male) stroke patients with gastrocnemius and / or soleus spasticity were included in this observational cross-sectional study. In clinical evaluation before and three months after BoNT injection; for spasticity evaluation modified Ashworth scale (MAS), pain assessment visual analog scale (VAS), functional evaluation; passive joint range of motion (ROM) measurement, functional independence measurement (FIM), lower limb Brunstrom staging, life quality assessment short form-36 (SF-36) quality of life scale, and sleep quality assessment Pittsburgh sleep quality index (PSQI) scales were used. Results: After the BoNT injection, there was a statistically significant decrease in MAS and VAS scores, a significant increase in passive ROM measurements, FIM, lower limb Brunstrom staging, and SF-36 physical function sub parameter. There was also a significant decrease in PSQI scores. Before and after treatment, there was no correlation found between PSQI values with pain and spasticity. However, there was a weak negative correlation between post-treatment PSQI values, passive ROM, SF-36 physical function and SF-36 physical role sub parameters (respectively: r: -0.335 p: 0.049, r: -0.364, 0.032, r: -0.404, p: 0.016). Conlusion: The results of our study suggest that BoNT, which is frequently used in the treatment of spasticity in stroke patients, has positive effects on sleep quality.

背景与目的：肉毒杆菌毒素（BoNT）是治疗中风相关性痉挛的常用药物。睡眠障碍通常可被视为中风患者的合并症或并发症。基于痉挛与睡眠障碍相关的数据，在这项研究中，我们旨在评估BoNT治疗的中风患者的睡眠质量是否已改变。方法：该观察性横断面研究包括了35例（17例女性/ 18例男性）中风腓肠肌和/或比目鱼肌痉挛。BoNT注射前后3个月的临床评估中；用于痉挛性评估改良Ashworth量表（MAS），疼痛评估视觉模拟量表（VAS），功能评估；被动关节运动范围（ROM）测量，功能独立性测量（FIM），下肢Brunstrom分期，生活质量评估（36型简表（SF-36））生活质量量表和睡眠质量评估匹兹堡睡眠质量指数（PSQI）使用天平。结果：BoNT注射后，MAS和VAS评分在统计学上显着降低，被动ROM测量，FIM，下肢Brunstrom分期和SF-36身体功能子参数显着增加。PSQI分数也显着下降。治疗前后，PSQI值与疼痛和痉挛之间没有相关性。但是，治疗后PSQI值，被动ROM，SF-36物理功能和SF-36物理角色子参数之间存在弱的负相关性（分别为：r：-0.335 p：0.049，r：-0.364，0.032，r ：-0.404，p：0.016）。结论：我们的研究结果表明，BoNT经常用于治疗中风患者的痉挛，对睡眠质量有积极影响。