Especially in orthopedics and implant applications, the bone cements are the main pillar of implants to form permanent bonds with the body. However, the main risk factor for implants is infection and loosening of the implant over time. This situation can seriously compromise patient comfort and even patient life. Therefore, superior mechanical strength, biocompatibility and antimicrobial properties are required for comfortable and healthy use. In this study, antibacterial bone cements synthesized as bone filler for application in orthopedic surgeries. Compositon was conducted by synthesing polymethyl methacrylate in the presence of curcumin, polyhedral oligomeric silsesquioxane (POSS), hydroxyapatite and free radical curable PEG functional quaternary polyethylenimine and were analyzed by using the methods of X-ray diffraction, Fourier Transform Infrared Spectroscopy, dynamic mechanical analysis and scanning electron microscopy. The inhibition zone areas and the surface activity resistances of the bone cement composites were analyzed against the bacteria Escherichia coli (E. coli), Listeria monositogenes (L. monositogenes), Salmonella and Staphylococcus aureus (S. aureus). Biocompatibility analysis was also applied via MTS assay. Analysis results confirm the suitable surface biocidal activity along with high cells viability of curcumin and pegylated quaternary polyethylene based bone cement, indicating its potentials for orthopedic applications.

特别是在骨科和植入物应用中，骨水泥是植入物与身体形成永久性结合的主要支柱。但是，植入物的主要危险因素是随着时间的推移感染和植入物松动。这种情况会严重损害患者的舒适度甚至患者的生命。因此，舒适和健康的使用需要优异的机械强度，生物相容性和抗菌性能。在这项研究中，抗菌骨水泥合成为骨填充物，用于整形外科。通过在姜黄素，多面体低聚倍半硅氧烷（POSS），羟基磷灰石和可自由基固化的PEG官能季铵亚胺的存在下合成聚甲基丙烯酸甲酯进行合成，并使用X射线衍射法进行分析，傅立叶变换红外光谱，动态力学分析和扫描电子显微镜。分析了骨水泥复合材料的抑菌圈面积和表面活性抗细菌性大肠杆菌（E. coli），李斯特菌（L. monositogenes），沙门氏菌和金黄色葡萄球菌（S. aureus）。生物相容性分析也通过MTS分析进行。分析结果证实了合适的表面杀生物活性以及姜黄素和聚乙二醇化季铵基聚乙烯基骨水泥的高细胞活力，表明其在骨科应用中的潜力。