Based on the PubMed data, we have been performing a yearly evaluation of the publications related to autoimmune diseases and immunology to ascertain the relative weight of the former in the scientific literature. It is particularly intriguing to observe that despite the numerous new avenues of immune-related mechanisms, such as cancer immunotherapy, the proportion of immunology manuscripts related to autoimmunity continues to increase and has been approaching 20% in 2019. As in the previous 13 years, we performed an arbitrary selection of the peer-reviewed articles published by the major dedicated Journals and discussed the common themes which continue to outnumber peculiarites in autoimmune diseases. The investigated areas included systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriatic arthritis (PsA), autoantibodies (autoAbs), and common therapeutic avenues and novel pathogenic mechanisms for autoimmune conditions. Some examples include new pathogenetic evidence which is well represented by IL21 or P2X7 receptor (P2X7R) in SLE or the application of single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq), and flow cytometry for the analysis of different cellular populations in RA. Cumulatively and of interest to the clinicians, a large number of findings continue to underline the importance of a strict relationship between basic and clinical science to define new pathogenetic and therapeutic developments. The therapeutic pipeline in autoimmunity continues to grow and maintain a constant flow of new molecules, as well illustrated in RA and PsA, and this is most certainly derived from the new basic evidence and the high-throughput tools applied to autoimmune diseases.

根据 PubMed 数据，我们每年都会对与自身免疫疾病和免疫学相关的出版物进行评估，以确定前者在科学文献中的相对权重。特别耐人寻味的是，尽管免疫相关机制的新途径众多，例如癌症免疫疗法，但与自身免疫相关的免疫学论文比例持续增加，2019 年已接近 20%。与前 13 年一样，我们对主要专业期刊发表的同行评议文章进行了任意选择，并讨论了在自身免疫疾病中继续超过特殊数量的共同主题。研究领域包括系统性红斑狼疮 (SLE)、类风湿性关节炎 (RA)、银屑病关节炎 (PsA)、自身抗体 (autoAbs)、以及自身免疫性疾病的常见治疗途径和新的致病机制。一些例子包括新的致病证据，由 SLE 中的 IL21 或 P2X7 受体 (P2X7R) 或单细胞 RNA 测序 (scRNA-seq)、质谱流式细胞术、批量 RNA 测序 (RNA-seq) 和流式细胞术的应用很好地代表用于分析 RA 中的不同细胞群。累积起来，临床医生感兴趣的是，大量发现继续强调基础科学和临床科学之间严格关系的重要性，以定义新的发病机制和治疗发展。自身免疫的治疗管道继续增长并保持新分子的恒定流动，这在 RA 和 PsA 中得到了说明，