Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barré syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barré syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.

中文翻译：

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SARS-CoV-2和Guillain-Barré综合征：以人类热激蛋白为潜在致病机制的分子模拟。

严重的急性呼吸综合征相关冠状病毒2感染已与格林-巴利综合征相关。我们在这里调查了病毒氨基酸序列，寻找与免疫介导的多发性神经病相关的人类自身抗原共有的肽，从而研究了病毒诱导的周围神经系统损害的潜在机制。我们的研究结果表明，病毒与人类热激蛋白90和60之间的分子模拟，与吉兰-巴雷综合征和其他自身免疫性疾病有关。至关重要的是，共享肽被嵌入到免疫反应性表位中，该表位已在人体宿主中进行了实验验证。