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Mononeuritis multiplex: an unexpectedly common feature of severe COVID-19
medRxiv - Neurology Pub Date : 2020-07-29 , DOI: 10.1101/2020.07.19.20149898
Edward Needham , Virginia Newcombe , Andrew Michell , Rachel Thornton , Andrew Grainger , Fahim Anwar , Elizabeth Warburton , David Menon , Monica Trivedi , Stephen Sawcer

The prolonged mechanical ventilation required by patients with severe COVID-19 is expected to result in significant Intensive Care Unit - Acquired Weakness (ICUAW) in many of the survivors. However, in our post-COVID-19 follow up clinic we have found that, as well as the anticipated global weakness related to loss of muscle mass, a significant proportion of these patients also have disabling focal neurological deficits relating to an axonal mononeuritis multiplex. Amongst the 69 patients with severe COVID-19 that have been discharged from the intensive care units in our hospital, we have seen 11 individuals (16%) with such neuropathies. In many instances, the multi-focal nature of the weakness in these patients was initially unrecognised as symptoms were wrongly assumed to simply relate to "critical illness neuropathy". While mononeuropathy is well recognised as an occasional complication of intensive care, our experience suggests that such deficits are common and frequently disabling in patients recovering from COVID-19.

中文翻译:

单发性神经炎:严重COVID-19的意外常见特征

患有严重COVID-19的患者所需的长时间机械通气预计将导致许多幸存者患上重症监护病房-获得性弱点(ICUAW)。但是,在我们的COVID-19后随访诊所中,我们发现,以及与肌肉量减少有关的预期的全身无力,这些患者中有很大一部分还患有与轴索性单神经炎多发有关的局灶性神经功能缺损。在我们医院的重症监护病房出院的69例严重COVID-19患者中,我们发现有11位患者(16%)患有这种神经病。在许多情况下,最初无法识别这些患者虚弱的多灶性,因为错误地认为症状仅与“重症神经病”有关。
更新日期:2020-07-29
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