The active form of vitamin D₃ is delivered and can also be generated in, e.g., keratinocytes and binds the nuclear receptor, vitamin D₃ receptor (VDR), leading to the expression of various target genes to modulate a wide range of immune responses. Oxarol ointment provides supraphysiological concentrations of active vitamin D₃ and is an effective and safe anti-inflammatory treatment for psoriasis. In the search for vaccine adjuvants that enhance specific aspects of the immune response, Ryota Sato et al. give mice an intra-dermal influenza H1N1 A/California/04/2009 split vaccine, then apply Oxarol once onto the same skin sites. This protects mice from otherwise lethal intra-nasal challenge by influenza virus. Anti-influenza antibody levels...

中文翻译：

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在这个问题上

递送维生素D ₃的活性形式，并且还可以在例如角质形成细胞中产生并结合核受体维生素D ₃受体（VDR），从而导致各种靶基因的表达以调节广泛的免疫反应。Oxarol软膏可提供生理活性维生素D _3的超生理浓度，是治疗牛皮癣的安全有效的消炎药。在寻找可增强免疫反应特定方面的疫苗佐剂时，Ryota Sato等人。给小鼠皮内注射H1N1 A / California / 04/2009流感疫苗，然后将Oxarol一次应用于相同的皮肤部位。这可以保护小鼠免受流感病毒对鼻内的致命杀伤。抗流感抗体水平...