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The Impact of Social and Behavioral Factors on Reproducibility in Terrestrial Vertebrate Models.
ILAR Journal ( IF 2.5 ) Pub Date : 2020-07-28 , DOI: 10.1093/ilar/ilaa005
Alexandra L Whittaker 1 , Debra L Hickman 2
Affiliation  

The use of animal models remains critical in preclinical and translational research. The reliability of the animal models and aspects of their validity is likely key to effective translation of findings to medicine. However, despite considerable uniformity in animal models brought about by control of genetics, there remain a number of social as well as innate and acquired behavioral characteristics of laboratory animals that may impact on research outcomes. These include the effects of strain and genetics, age and development, sex, personality and affective states, and social factors largely brought about by housing and husbandry. In addition, aspects of the testing environment may also influence research findings. A number of considerations resulting from the animals’ innate and acquired behavioral characteristics as well as their social structures are described. Suggestions for minimizing the impact of these factors on research are provided.

中文翻译:

社会和行为因素对陆生脊椎动物模型再现性的影响。

动物模型的使用在临床前和转化研究中仍然至关重要。动物模型的可靠性及其有效性方面可能是将研究结果有效转化为医学的关键。然而,尽管遗传学控制导致动物模型相当一致,但实验室动物的许多社会以及先天和后天的行为特征可能会影响研究结果。其中包括应变和遗传、年龄和发育、性别、个性和情感状态的影响,以及主要由住房和畜牧业带来的社会因素。此外,测试环境的各个方面也可能影响研究结果。描述了由动物的先天和后天行为特征以及它们的社会结构引起的许多考虑因素。提供了尽量减少这些因素对研究的影响的建议。
更新日期:2020-07-28
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