Abstract

Oxidative stress is the main player in the development of diabetic vascular complications. Co-Q10 is a natural antioxidant present in the body and in many foods. This study was designed to evaluate the effect of Co-Q10 administration to improve vascular complications and increase insulin sensitivity in diabetic rats. Fifty male rats were divided into five groups: control, diabetic untreated, diabetic insulin-treated, diabetic Co-Q10-treated, and diabetic combined-treated groups. After 8 weeks, blood pressure and vascular reactivity to NE and ACh, fasting glucose, insulin, C-peptide, MDA, TAC, HbA1c, and the HOMA-IR were measured. Diabetes increased fasting glucose, HbA1c, HOMA-IR, MDA, blood pressure, and decreased TAC and vascular reactivity. Ttreatment with insulin or Co-Q10 improved glycemic parameters and increasing antioxidant levels compared to diabetic group. Combined Co-Q10 with insulin was found to increase insulin sensitivity and decrease its resistance, which helps to decrease insulin doses in diabetic patients and reduce its side effects.

摘要

氧化应激是糖尿病血管并发症发生的主要参与者。辅酶 Q10 是一种存在于人体和许多食物中的天然抗氧化剂。本研究旨在评估辅酶 Q10 给药对改善糖尿病大鼠血管并发症和增加胰岛素敏感性的作用。将 50 只雄性大鼠分为五组：对照组、糖尿病未治疗组、糖尿病胰岛素治疗组、糖尿病辅酶 Q10 治疗组和糖尿病联合治疗组。8 周后，测量血压和血管对 NE 和 ACh 的反应性、空腹血糖、胰岛素、C 肽、MDA、TAC、HbA1c 和 HOMA-IR。糖尿病会增加空腹血糖、HbA1c、HOMA-IR、MDA、血压，并降低 TAC 和血管反应性。与糖尿病组相比，用胰岛素或辅酶 Q10 治疗可改善血糖参数并增加抗氧化水平。Co-Q10 与胰岛素联合使用可增加胰岛素敏感性并降低其抵抗力，这有助于减少糖尿病患者的胰岛素剂量并减少其副作用。