Secreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to combat oxidative stress in the central nervous system. Melatonin-based therapies have been shown to provide neuroprotective effects in the setting of ischemic stroke by mitigating neuroinflammation and accelerating brain tissue restoration. Melatonin treatment includes injection of exogenous melatonin, pineal gland grafting and melatonin-mediated stem cell therapy. This review will discuss the current preclinical and clinical studies investigating melatonin-based therapeutics to treat stroke.

中文翻译：

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褪黑激素-一种有效的中风和中风相关痴呆疗法。

褪黑素由松果体分泌，调节昼夜节律，是一种强大的抗氧化剂，已被用来对抗中枢神经系统的氧化应激。已经证明，基于褪黑激素的疗法可减轻神经炎症并加速脑组织恢复，从而在缺血性中风的发生中提供神经保护作用。褪黑激素治疗包括注射外源性褪黑激素，松果体移植和褪黑激素介导的干细胞治疗。本文将讨论目前基于褪黑素治疗中风的临床前和临床研究。