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Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity in teleosts.
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-08-11 , DOI: 10.1073/pnas.1921856117
Dina Navon 1 , Ira Male 2 , Emily R Tetrault 2 , Benjamin Aaronson 3 , Rolf O Karlstrom 3 , R Craig Albertson 4
Affiliation  

Phenotypic plasticity, the ability of a single genotype to produce multiple phenotypes under different environmental conditions, is critical for the origins and maintenance of biodiversity; however, the genetic mechanisms underlying plasticity as well as how variation in those mechanisms can drive evolutionary change remain poorly understood. Here, we examine the cichlid feeding apparatus, an icon of both prodigious evolutionary divergence and adaptive phenotypic plasticity. We first provide a tissue-level mechanism for plasticity in craniofacial shape by measuring rates of bone deposition within functionally salient elements of the feeding apparatus in fishes forced to employ alternate foraging modes. We show that levels and patterns of phenotypic plasticity are distinct among closely related cichlid species, underscoring the evolutionary potential of this trait. Next, we demonstrate that hedgehog (Hh) signaling, which has been implicated in the evolutionary divergence of cichlid feeding architecture, is associated with environmentally induced rates of bone deposition. Finally, to demonstrate that Hh levels are the cause of the plastic response and not simply the consequence of producing more bone, we use transgenic zebrafish in which Hh levels could be experimentally manipulated under different foraging conditions. Notably, we find that the ability to modulate bone deposition rates in different environments is dampened when Hh levels are reduced, whereas the sensitivity of bone deposition to different mechanical demands increases with elevated Hh levels. These data advance a mechanistic understanding of phenotypic plasticity in the teleost feeding apparatus and in doing so contribute key insights into the origins of adaptive morphological radiations.



中文翻译:

刺猬信号对于调节硬骨鱼的颅面可塑性是必要且充分的。

表型可塑性,即单一基因型在不同环境条件下产生多种表型的能力,对于生物多样性的起源和维持至关重要;然而,可塑性背后的遗传机制以及这些机制的变异如何推动进化变化仍然知之甚少。在这里,我们研究了丽鱼科鱼的摄食装置,它是巨大的进化分歧和适应性表型可塑性的标志。我们首先通过测量被迫采用交替觅食模式的鱼类进食装置的功能显着元件内的骨沉积率,提供了颅面形状可塑性的组织级机制。我们表明,表型可塑性的水平和模式在密切相关的慈鲷物种中是不同的,强调了这一特征的进化潜力。接下来,我们证明与丽鱼科鱼摄食结构的进化分歧有关的刺猬 (Hh) 信号与环境诱导的骨沉积率有关。最后,为了证明 Hh 水平是塑性反应的原因,而不仅仅是产生更多骨骼的结果,我们使用转基因斑马鱼,其中可以在不同的觅食条件下通过实验控制 Hh 水平。值得注意的是,我们发现当 Hh 水平降低时,在不同环境中调节骨沉积速率的能力会减弱,而骨沉积对不同机械需求的敏感性会随着 Hh 水平升高而增加。

更新日期:2020-08-11
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