Diethyl 2-(perfluorophenyl)malonate was synthesized in 47% isolated yield by the reaction of sodium diethyl malonate and hexafluorobenzene. The resulting compound was considered as a starting material for synthesizing 2-(perfluorophenyl)malonic acid by hydrolysis. It was found that the desired 2-(perfluorophenyl)malonic acid could not be obtained from this ester by hydrolysis, neither under basic nor under acidic conditions. Nevertheless, hydrolysis of the ester with a mixture of HBr and AcOH gave 2-(perfluorophenyl)acetic acid in a good preparative yield of 63%. A significant advantage of this new approach to 2-(perfluorophenyl)acetic acid is that handling toxic substances such as cyanides and perfluorinated benzyl halides is avoided.

中文翻译：

---

关于2-（全氟苯基）丙二酸二乙酯的水解。

通过丙二酸二乙酯钠和六氟苯的反应，合成了（全氟苯基）丙二酸二乙酯，分离产率为47％。所得化合物被认为是通过水解合成2-（全氟苯基）丙二酸的原料。已发现，无论是在碱性条件下还是在酸性条件下，都无法通过水解从该酯中获得所需的2-（全氟苯基）丙二酸。然而，用HBr和AcOH的混合物将酯水解，得到63％的良好制备产率的2-（全氟苯基）乙酸。这种新的2-（全氟苯基）乙酸方法的显着优点是避免了处理有毒物质，例如氰化物和全氟苄基卤。