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It wasn't supposed to be a coronavirus: The quest for an influenza A(H5N1)-derived vaccine and the limits of pandemic preparedness
Centaurus ( IF 1.2 ) Pub Date : 2020-05-01 , DOI: 10.1111/1600-0498.12312
Brian Dolan 1
Affiliation  

The COVID-19 pandemic has raised questions about what efforts were made across the world to prepare governments and healthcare systems for such an event. This spotlight article looks at developments made in “pre-pandemic preparedness planning” following a number of outbreaks of influenza type A virus in 1997. At that time, a specific avian influenza subtype, referred to as A(H5N1), wreaked havoc among fowl but also infected humans through direct transmission. The potential for slight genetic mutations that could make A(H5N1) more infectious, allowing human-to-human transmission, presented the threat of a deadly influenza pandemic. As a result, the U.S. government (and others coordinating through the World Health Organization) launched a pandemic preparation plan, including strategies to develop vaccines against A(H5N1) and its genetic lineages each year. This spotlight article discusses the events that led to the specific concern about A(H5N1) among public health officials, as well as early efforts to derive and stockpile an appropriate vaccine to protect against a possible pandemic. This perspective presents the challenges the world has faced, in recent history, in striving to keep one step ahead of pandemic threats.

中文翻译:

它不应该是冠状病毒:对甲型流感 (H5N1) 衍生疫苗的探索和大流行准备的局限性

COVID-19 大流行引发了人们的疑问,即世界各地为政府和医疗保健系统为此类事件做准备做了哪些努力。这篇重点文章着眼于 1997 年 A 型流感病毒爆发后“大流行前准备计划”的进展。 当时,一种特定的禽流感亚型,称为 A(H5N1),对家禽造成了严重破坏但也通过直接传播感染了人类。微小的基因突变可能使 A(H5N1) 更具传染性,从而导致人与人之间的传播,这带来了致命流感大流行的威胁。因此,美国政府(以及通过世界卫生组织协调的其他方面)启动了大流行准备计划,包括每年开发针对 A(H5N1) 及其遗传谱系的疫苗的策略。这篇焦点文章讨论了导致公共卫生官员对 A(H5N1) 产生特别关注的事件,以及为预防可能的大流行而开发和储存适当疫苗的早期努力。这一观点展示了世界在近代历史上在努力领先于流行病威胁方面所面临的挑战。
更新日期:2020-05-01
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