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Exposure to bisphenols and asthma morbidity among low-income urban children with asthma
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2020-07-28 , DOI: 10.1016/j.jaci.2020.05.031
Lesliam Quirós-Alcalá 1 , Nadia N Hansel 2 , Meredith McCormack 2 , Antonia M Calafat 3 , Xiaoyun Ye 3 , Roger D Peng 4 , Elizabeth C Matsui 5
Affiliation  

Background

Bisphenol A (BPA) has been linked with pediatric asthma development and allergic airway inflammation in animal models. Whether exposure to BPA or its structural analogs bisphenol S (BPS) and bisphenol F (BPF) is associated with asthma morbidity remains unknown.

Objective

We examined associations between bisphenols and morbidity due to pediatric asthma.

Methods

We quantified concentrations of BPA, BPS, and BPF in 660 urine samples from 148 predominantly low-income, African American children (aged 5-17 years) with established asthma. We used biobanked biospecimens and data on symptoms, health care utilization, and pulmonary function and inflammation that were collected every 3 months over the course of a year. We used generalized estimating equations to examine associations between concentrations or detection of urinary bisphenols and morbidity outcomes and assessed heterogeneity of associations by sex.

Results

We observed consistent positive associations between BPA exposure and measures of asthma morbidity. For example, we observed increased odds of general symptom days (adjusted odds ratio [aOR] = 1.40 [95% C = 1.02-1.92]), maximal symptom days (aOR = 1.36 [95% CI = 1.00-1.83]), and emergency department visits (aOR = 2.12 [95% CI =1.28-3.51]) per 10-fold increase in BPA concentration. We also observed evidence of sexually dimorphic effects; BPA concentrations were associated with increased odds of symptom days and health care utilization only among boys. Findings regarding BPS and BPF did not consistently point to associations with asthma symptoms or health care utilization.

Conclusion

We found evidence to suggest that BPA exposure in a predominantly low-income, minority pediatric cohort is associated with asthma morbidity and that associations may differ by sex. Our findings support additional studies, given the high pediatric asthma burden and widespread exposure to BPA in the United States.



中文翻译:

低收入城市哮喘儿童的双酚暴露与哮喘发病率

背景

在动物模型中,双酚 A (BPA) 与儿童哮喘发展和过敏性气道炎症有关。暴露于 BPA 或其结构类似物双酚 S (BPS) 和双酚 F (BPF) 是否与哮喘发病率相关仍然未知。

客观的

我们检查了双酚与儿童哮喘引起的发病率之间的关联。

方法

我们量化了来自 148 名主要是低收入非洲裔美国儿童(5-17 岁)的 660 份尿样中 BPA、BPS 和 BPF 的浓度,这些儿童患有哮喘。我们使用了在一年中每 3 个月收集一次的生物样本和有关症状、医疗保健利用、肺功能和炎症的数据。我们使用广义估计方程来检查浓度或尿双酚检测与发病结果之间的关联,并评估性别关联的异质性。

结果

我们观察到 BPA 暴露与哮喘发病率测量之间存在一致的正相关。例如,我们观察到一般症状天数增加(调整优势比 [aOR] = 1.40 [95% C = 1.02-1.92])、最大症状天数(aOR = 1.36 [95% CI = 1.00-1.83])和BPA 浓度每增加 10 倍,急诊就诊次数 (aOR = 2.12 [95% CI =1.28-3.51])。我们还观察到了性二态效应的证据;BPA 浓度仅与男孩出现症状天数和医疗保健利用的几率增加有关。关于 BPS 和 BPF 的研究结果并未始终指出与哮喘症状或医疗保健利用的关联。

结论

我们发现有证据表明,在主要是低收入、少数族裔的儿科队列中,BPA 暴露与哮喘发病率相关,并且这种关联可能因性别而异。鉴于美国儿童哮喘负担高且广泛接触 BPA,我们的研究结果支持进一步的研究。

更新日期:2020-07-28
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