Cell Stem Cell ( IF 23.9 ) Pub Date : 2020-07-28 , DOI: 10.1016/j.stem.2020.07.002 Paloma Navarro Negredo 1 , Robin W Yeo 1 , Anne Brunet 2
Aging has a profound and devastating effect on the brain. Old age is accompanied by declining cognitive function and enhanced risk of brain diseases, including cancer and neurodegenerative disorders. A key question is whether cells with regenerative potential contribute to brain health and even brain “rejuvenation.” This review discusses mechanisms that regulate neural stem cells (NSCs) during aging, focusing on the effect of metabolism, genetic regulation, and the surrounding niche. We also explore emerging rejuvenating strategies for old NSCs. Finally, we consider how new technologies may help harness NSCs’ potential to restore healthy brain function during physiological and pathological aging.
中文翻译:
神经干细胞及其壁龛的衰老和再生。
衰老对大脑具有深远而毁灭性的影响。老年伴随着认知功能下降和脑部疾病风险增加,包括癌症和神经退行性疾病。一个关键问题是具有再生潜力的细胞是否有助于大脑健康甚至大脑“恢复活力”。本综述讨论了衰老过程中调节神经干细胞 (NSC) 的机制,重点关注代谢、遗传调节和周围生态位的影响。我们还探索了旧 NSC 的新兴复兴策略。最后,我们考虑新技术如何帮助利用神经干细胞在生理和病理衰老过程中恢复健康的大脑功能的潜力。