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Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications
Fibers and Polymers ( IF 2.5 ) Pub Date : 2020-07-27 , DOI: 10.1007/s12221-020-9856-1
Rashmi , Rimpy , Munish Ahuja

The purpose of the present work was to modify the absorbent cotton gauze to improve its functionality as antimicrobial wound dressing. The cotton gauze was modified by grafting of N-vinyl-pyrrolidone using microwave-assisted reactions. The effect of volume of N-vinyl-pyrrolidone and amount of ammonium persulfate on percentage grafting was optimized by 2-factor, 3-level central composite experimental design. The optimized batch of gauze-g-NVP was impregnated with iodine. The iodine-loaded gauze-g-NVP was characteristically examined by Fourier-transformed infrared spectroscopy and Field emission-scanning electron microscopy studies. The results of energy dispersive X-ray analysis confirmed the uniform dispersion of iodine on the surface of iodine impregnated poly(NVP)-g-cotton gauze. Further, the iodine-loaded gauze-g-NVP showed blood absorbency and in vitro blood clotting ability comparable to the absorbent cotton gauze. However, a significantly higher antimicrobial activity of iodine-loaded gauze-g-NVP against the Staphylococcus aureus and Escherichia coli was observed as compared to the iodine solution of equivalent concentration which can be attributed to the higher retention of iodine at the site of action. In the nutshell, results show that iodine-loaded grafted cotton gauze have the desirable and effective antibacterial wound dressing property with excellent blood absorbency and clotting abilities.



中文翻译:

用于伤口敷料的碘浸渍的聚(N-乙烯基吡咯烷酮)接枝抗菌棉纱布

本发明的目的是修饰吸收性棉纱布以改善其作为抗菌伤口敷料的功能。通过微波辅助反应接枝N-乙烯基吡咯烷酮来修饰棉纱布。通过2因子3级中心复合实验设计优化了N-乙烯基吡咯烷酮的体积和过硫酸铵的量对接枝率的影响。优化的纱布-g-NVP批料浸有碘。通过傅里叶变换红外光谱和场发射扫描电子显微镜研究对碘负载的纱布-g-NVP进行了特征检查。能量色散X射线分析的结果证实了碘在浸有碘的聚(NVP)-g-棉纱布表面上的均匀分散。此外,载有碘的纱布-g-NVP表现出血液吸收能力,并且体外血液凝结能力堪比吸收性棉纱布。然而,与等浓度的碘溶液相比,观察到负载碘的纱布-g-NVP对金黄色葡萄球菌大肠杆菌具有显着更高的抗菌活性,这可以归因于碘在作用部位的保留更高。简而言之,结果表明,负载碘的接枝棉纱布具有令人满意的,有效的抗菌伤口敷料性能,并具有出色的血液吸收能力和凝结能力。

更新日期:2020-07-28
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