The manuscript reports synthesis and antimicrobial activity of several novel heterocyclic compounds in which 1,4-disubstituted 1,2,3-triazole synthesized via click chemistry approach and 4-aryl (5a-h) and 4-piperazinyl amide (7a-e) or 4-aryl amide (8a-e) substituted thiazole rings, are bridged through hydrazine linkage. Structures of all the synthesized compounds have been elucidated using ¹H and ¹³C NMR and mass spectral analysis. In vitro antimicrobial screening of the target compounds has been carried out against six bacterial species viz. E. coli, P. aeruginosa, B. subtilis, S. pyogenes, K. pneumoniae and S. aureus and four fungal species viz. C. albicans, T. viride, A. flavus and A. brasiliensis. The activity study revealed that many of the compounds possess moderate to good activity against the tested microorganisms. The active compounds have been further studied to determine the minimum inhibitory concentration (MIC).

中文翻译：

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1-（2,6-二氟苄基）-1H-1,2,3-三唑-4-甲醛的4-取代噻唑-2-基肼衍生物的合成和抑菌活性

该手稿报告了几种新型杂环化合物的合成和抗菌活性，其中通过点击化学方法合成了1,4-二取代的1,2,3-三唑以及4-芳基（5a-h）和4-哌嗪基酰胺（7a-e）或4-芳基酰胺（8a-e）取代的噻唑环通过肼键桥接。使用¹ H和¹³ C NMR和质谱分析已阐明了所有合成化合物的结构。体外目标化合物的抗微生物筛选已对六种细菌物种进行即。大肠杆菌，铜绿假单胞菌，枯草芽孢杆菌，酿脓链球菌，肺炎克雷伯菌和金黄色葡萄球菌和四个真菌物种即。C.白色念珠菌，T.viride，A。flavus和A.brasiliensis。活性研究表明，许多化合物对被测微生物具有中等至良好的活性。已经对活性化合物进行了进一步研究，以确定最小抑菌浓度（MIC）。