A series of novel 5-arylidene-thiazolidine-2,4-diones derivatives have been synthesized by the Knoevenagel condensation of aromatic aldehydes and N-substituted thiazolidinedione-2,4-diones. Use of KAl(SO₄)₂•12(H₂O) i.e. Alum for the reaction makes this synthesis facile because of several advantageous factors viz. non-toxicity, efficient catalytic ability and cheap cost of alum. Substitution of arylidene moiety at the position 5 on the thiazolidine-2,4-diones nucleus has occured using this facile approach. Synthesized derivatives have been characterized using various analytical tools and antimicrobial evaluation thereof has been performed against Gram-positive, Gram negative bacteria and a fungal strain. All synthesized compounds show moderate to very good activity against the microorganisms that they have been tested against.

中文翻译：

---

一些新型5-芳基-噻唑烷-2,4-二酮的简便合成，表征及其抗菌性能

通过芳族醛和N-取代的噻唑烷二酮-2,4-二酮的Knoevenagel缩合反应，已经合成了一系列新型的5-亚芳基-噻唑烷-2,4-二酮衍生物。使用KAl（SO ₄）₂ •12（H ₂ O）i。e。明矾用于反应使得由于若干有利因素此合成容易即。无毒，有效的催化能力和廉价的明矾成本。使用这种简便的方法已经取代了噻唑烷-2,4-二酮核上第5位的亚芳基部分。已经使用各种分析工具表征了合成的衍生物，并且已经对革兰氏阳性，革兰氏阴性细菌和真菌菌株进行了抗菌评估。所有合成的化合物对被测试的微生物均表现出中等至非常好的活性。