Towards the synthesis of C43 to C51 unit of Amphidinol-3 has been achieved following our recently developed protocol for the highly stereoselective synthesis of trans-2,6-disubstituted dihydropyran through tandem isomerization followed by C–O and C–C bond formation reaction as the key steps. The other important reactions involved are cross-metathesis (CM) reaction and Jin’s protocol.

中文翻译：

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合成Amphidinol-3的C43至C51单元

遵循我们最近开发的协议，通过串联异构化，随后的C–O和C–C键形成反应高度立体选择性地合成反式-2,6-二取代的二氢吡喃，可以实现Amphidinol-3的C43至C51单元的合成。关键步骤。涉及的其他重要反应是交叉复分解（CM）反应和Jin的方案。