One-pot multi-component synthesis of tri and tetra-substituted coumarin-imidazole conjugates have been achieved in good to excellent yield under conventional and microwave methods in optimized catalyst condition. Further, they have been evaluated for antimicrobial activity against Gram positive Bacillus flexus and Gram negative Pseudomonas Spp. bacterial strains and two strains of fungi Scopulariopsis spp. and Aspergillus tereus organisms. The results of microbial activity are promising against tested organisms. The molecular docking study has been performed for all the compounds and docking scores are excellent. Synthesized compounds have been characterized by IR, NMR, mass and a few of them by single crystal X-ray analysis.

中文翻译：

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香豆素-咪唑共轭物作为潜在抗菌剂的合成及分子对接研究

在常规和微波方法下，在优化的催化剂条件下，以良好或优异的产率实现了三和四取代香豆素-咪唑共轭物的一锅多组分合成。此外，已经评估了它们对革兰氏阳性弯曲杆菌和革兰氏阴性假单胞菌Spp的抗菌活性。细菌菌株和两种真菌Scopulariopsis spp。和曲霉菌。微生物活性的结果有望针对被测生物。已经对所有化合物进行了分子对接研究，对接分数非常好。合成的化合物已通过IR，NMR，质量进行了表征，其中一些通过单晶X射线分析得以表征。