Heavy metals have caused a lot of imbalance in the environment due to its widespread ill effects. There have been tremendous efforts to reduce the levels of these metals from the environment, but demerits of existing methods exceed over the merits in most of the cases and hence there is a need for more effective mechanisms. In the present study, resistance profile of Candida parapsilosis was studied against various heavy metals. A time based tolerance study was performed using up to 12 mM concentrations of heavy metal salts such as zinc sulfate (Zn), cupric sulfate (Cu), lead acetate (Pb), mercury chloride (Hg), nickel sulfate (Ni), and potassium chromate (Cr). It was observed that tolerance against heavy metal depends upon its concentration as well as time of exposure. The obtained pattern of resistance for each individual heavy metal was Ni > Zn > Cu > Cr > Pb > Hg. Maximum growth of 57.6% was obtained for Ni salt and least for Hg with 26.9% cell viability at 12 mM concentration. Cell viability decreased as time of exposure was increased. After 72 h only 16.4% cell growth was obtained for Hg as compared to Ni showing cell viability of 37.5% up to 12 mM concentration. Significant resistance to other salts such as Zn, Cu, Cr and Pd have also been shown by C. parapsilosis.

中文翻译：

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副念珠菌对重金属的抵抗力评估

重金属由于其广泛的不良影响而导致环境中的许多失衡。为了减少环境中这些金属的含量，已经进行了巨大的努力，但是在大多数情况下，现有方法的弊端超过了优点，因此需要一种更有效的机制。在本研究中，副念珠菌的抗药性针对各种重金属进行了研究。基于时间的耐受性研究使用了浓度高达12 mM的重金属盐，例如硫酸锌（Zn），硫酸铜（Cu），醋酸铅（Pb），氯化汞（Hg），硫酸镍（Ni）和铬酸钾（Cr）。据观察，对重金属的耐受性取决于其浓度以及暴露时间。每种重金属的电阻模式为Ni> Zn> Cu> Cr> Pb> Hg。在12 mM浓度下，Ni盐的最大生长量为57.6％，Hg的最小生长量为26.9％。细胞活力随着暴露时间的增加而降低。在72小时后，与Ni相比，仅获得16.4％的Hg细胞生长，显示出直至12mM浓度的细胞存活率为37.5％。C.寄生虫病。