Hypothyroidism a quite common thyroid disorder is often associated with anemia. Osmotic fragility is altered with an alteration of the thyroid profile. Hypothyroidism induced reduction of membrane cholesterol and compromised the activity of Na+K+ATPase and increased peroxidation of membrane lipids appear to be responsible for damaging the red blood corpuscle (RBC) membranes which alter the permeability of themembrane and thus ionic environment within the cell. The objective of this study was to evaluate the relation between the association of hypothyroidism and RBC membrane lipid peroxidation in the development of increased RBC osmotic fragility. A complete clinical history and biochemical investigations, including thyroid function tests namely, thyroid -stimulating hormone (TSH) and free T4 (fT4), RBC membrane osmotic fragility test by gradient concentration of NaCl, and RBC membrane peroxidation using thiobarbituric acid reactive substances (TBARS) tests were performed among thirty two hypothyroidism patients and healthy controls. Serum TSH & TBARS in the RBC membrane were significantly higher (P <0.001) than healthy controls which also showed a significant positive correlation (r =0.8, P =0.01) when compared without grouping. Osmotic fragility of RBC was found significantly increased among hypothyroid patients (P <0.001) at NaCl conc. of 0.3%, 0.4%, 0.5% & (P <0.05) at NaCl conc. of 0.6%. In conclusion, the results indicated that RBC osmotic fragility increases significantly in hypothyroidism possibility due to increased membrane lipid peroxidation as observed in the study.

中文翻译：

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甲状腺功能减退症中红细胞渗透脆性增加

甲状腺功能减退甲状腺功能低下是一种非常常见的甲状腺疾病，通常与贫血有关。渗透脆性随甲状腺特征的改变而改变。甲状腺功能减退症引起的膜胆固醇降低并损害了Na + K + ATPase的活性，并且膜脂质的过氧化作用增加，可能是破坏红细胞（RBC）膜的原因，从而改变了膜的通透性，从而改变了细胞内的离子环境。这项研究的目的是评估甲状腺功能减退症和RBC膜脂质过氧化之间的关系，以增加RBC渗透脆性的发展。完整的临床病史和生化检查，包括甲状腺功能测试，即促甲状腺激素（TSH）和游离T4（fT4），在32名甲状腺机能减退症患者和健康对照组中，通过NaCl梯度浓度进行RBC膜渗透性脆性测试，并使用硫代巴比妥酸反应性物质（TBARS）测试RBC膜过氧化作用。与未分组时相比，RBC膜中的血清TSH和TBARS显着高于健康对照组（P <0.001），后者也显示出显着正相关（r = 0.8，P = 0.01）。甲状腺功能减退的甲状腺功能减退患者中，RBC的渗透脆性显着增加（P <0.001）。NaCl浓度为0.3％，0.4％，0.5％和（P <0.05）为0.6％。总之，结果表明，如研究中所观察到的，由于膜脂质过氧化增加，RBC渗透性脆性在甲状腺功能减退的可能性中显着增加。在32例甲状腺功能减退症患者和健康对照中进行了硫代巴比妥酸反应物质（TBARS）检测和RBC膜过氧化。与未分组时相比，RBC膜中的血清TSH和TBARS显着高于健康对照组（P <0.001），后者也显示出显着正相关（r = 0.8，P = 0.01）。甲状腺功能减退的甲状腺功能减退患者中，RBC的渗透脆性显着增加（P <0.001）。NaCl浓度为0.3％，0.4％，0.5％和（P <0.05）为0.6％。总之，结果表明，如研究中所观察到的，由于膜脂质过氧化增加，RBC渗透性脆性在甲状腺功能减退的可能性中显着增加。在32例甲状腺功能减退症患者和健康对照中进行了硫代巴比妥酸反应物质（TBARS）检测和RBC膜过氧化。与未分组时相比，RBC膜中的血清TSH和TBARS显着高于健康对照组（P <0.001），后者也显示出显着正相关（r = 0.8，P = 0.01）。甲状腺功能减退的甲状腺功能减退患者中，RBC的渗透脆性显着增加（P <0.001）。NaCl浓度为0.3％，0.4％，0.5％和（P <0.05）为0.6％。总之，结果表明，如研究中所观察到的，由于膜脂质过氧化增加，RBC渗透脆性在甲状腺功能减退的可能性中显着增加。