We describe a deterministic lateral displacement (DLD) for particle separation with only a single column of bumping features. The bifurcation of fluid streams at obstacles is not set by the “tilt” of columns with respect to macroscopic current flow, but rather by the fluidic resistances for lateral flow at each obstacle. With one column of 14 bumping features and corresponding inlet/outlet channels, the single-column DLD can separate particles with diameters of 4.8 μm and 9.9 μm at 30 μL min⁻¹, with an area of only 0.37 mm × 1.5 mm (0.55 mm²). The large-cell output contains over 99% of the 9.9 μm particles and only 0.2% of the 4.8 m particles. The throughput per area of 54 μL min⁻¹ per mm² represents a 10× increase over previous selective harvesting reports for microfluidic devices in a similar particle size range.

中文翻译：

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将确定性横向位移装置缩放到单列颠簸障碍物。

我们描述了用于粒子分离的确定性横向位移 (DLD)，只有一列碰撞特征。障碍物处流体流的分叉不是由柱相对于宏观电流流动的“倾斜”决定的，而是由每个障碍物侧向流动的流体阻力决定的。单柱 DLD 具有 14 个碰撞功能和相应的入口/出口通道，可在 30 μL min ^-1时分离直径为 4.8 μm 和 9.9 μm 的颗粒，面积仅为 0.37 mm × 1.5 mm (0.55 mm ² )。大电池输出包含超过 99% 的 9.9 μm 颗粒和仅 0.2% 的 4.8 m 颗粒。^{54 μL min -1}每 mm ²的单位面积通量与之前对类似粒径范围的微流体装置的选择性收获报告相比，增加了 10 倍。