Innate immunity plays a central role in the pathogenesis of chronic inflammatory enteropathies (CIE) in dogs, and further evaluation of the innate immune receptor for advanced glycation end-products (RAGE) is warranted. We measured serum concentrations of decoy receptor soluble RAGE (sRAGE) in 102 dogs diagnosed with CIE, and evaluated relationships with clinical disease severity, histologic lesion severity, concentrations of serum C-reactive protein (CRP), and serum and fecal calprotectin, S100A12, and alpha₁-proteinase inhibitor (α₁PI). Serum sRAGE levels were not associated with clinical disease activity, serum CRP, serum and fecal α₁PI, calprotectin, or S100A12 concentrations. Microscopic lesions in the duodenum were more severe in dogs with serum sRAGE concentration ≤ 340 ng/L (p = 0.013). Serum sRAGE levels were weakly and inversely correlated with the severity of lymphoplasmacytic infiltration in the gastric antrum and duodenum, and with crypt dilation and the neutrophilic infiltrate in the duodenum, in univariate analysis (all p < 0.05), but none of the correlations remained statistically significant after correction for multiple comparisons. Our study confirms that CIE in dogs is associated with decreased serum sRAGE concentrations, suggesting a dysregulated sRAGE/RAGE axis.

先天免疫在犬慢性炎性肠病（CIE）的发病机理中起着关键作用，因此有必要进一步评估先天免疫受体对晚期糖基化终产物（RAGE）的作用。我们测量了102例诊断为CIE的狗的诱饵受体可溶性RAGE（sRAGE）的血清浓度，并评估了其与临床疾病严重性，组织病变严重性，血清C反应蛋白（CRP）浓度以及血清和粪便钙卫蛋白S100A12的关系，和α ₁ -蛋白酶抑制剂（α _1个PI）。血清的sRAGE水平与临床疾病活性，血清CRP，血清和粪便α相关联的₁PI，钙卫蛋白或S100A12浓度。血清sRAGE浓度≤340 ng / L的狗十二指肠镜下病变更为严重（p  = 0.013）。在单变量分析中，血清sRAGE水平与胃窦和十二指肠中淋巴浆细胞浸润的严重程度，十二指肠中隐窝扩张和嗜中性浸润的程度呈弱和负相关（所有p  <0.05），但均无统计学意义多次比较校正后具有显着性。我们的研究证实，狗的CIE与血清sRAGE浓度降低有关，提示sRAGE / RAGE轴失调。