Chemokines are a family of small molecular-weight proteins, being well-known with their important roles in the process of allergic response, immune regulation, cell proliferation, and differentiation. Almost two decades ago, a novel member of this family, chemokine-like factor 1 (CKLF1) was identified. In recent years, it draws much attention of researchers because of its key roles in many types of tissues and its potential implications in a large number of diseases. Up to now, CKLF1 has been shown to have two main functions: broad-spectrum chemotactic activity, and proliferation- and differentiation-promoting abilities. In this review, we would introduce the basic structural features of CKLF1 and its biological functions, and then elaborate the relationships between CKLF1 and human diseases. The cell signaling pathways CKLF1 may be involved in would be discussed and summarized in details. Furthermore, we present the trials of CKLF1-targeted treatments in animal disease models, hoping to provide a few important insights about CKLF1 to both medical researchers and pharmacy, and finally conclude that CKLF1 is a potent, and very promising, therapeutic target.

Impact statement

CKLF1, a recently identified chemokine, has been reported by a number of studies to play important roles in quite many diseases. However, the potential pathways that CKLF1 may be involved are not manifested well yet. In our review, we showed the basic molecular structure and major functions of this novel chemokine, and implication in human diseases, such as tumors. To attract more attention, we summarized its signaling pathways and clearly present them in a set of figures. With the overview of the experimental trial of CKLF1-targeting medicines in animal models, we hope to provide a few important insights about CKLF1 to both medical researchers and pharmacy.

中文翻译：

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趋化因子样因子 1：人类疾病的一个有希望的治疗靶点。

趋化因子是一个小分子蛋白家族，在过敏反应、免疫调节、细胞增殖和分化过程中发挥着重要作用。大约二十年前，该家族的一个新成员，趋化因子样因子 1 (CKLF1) 被鉴定出来。近年来，它因其在多种类型组织中的关键作用及其在大量疾病中的潜在影响而受到研究人员的广泛关注。迄今为止，CKLF1 已被证明具有两个主要功能：广谱趋化活性和促进增殖和分化的能力。在这篇综述中，我们将介绍CKLF1的基本结构特征及其生物学功能，然后阐述CKLF1与人类疾病的关系。将详细讨论和总结CKLF1可能参与的细胞信号通路。此外，我们展示了 CKLF1 靶向治疗在动物疾病模型中的试验，希望为医学研究人员和药学提供一些关于 CKLF1 的重要见解，并最终得出结论，CKLF1 是一种有效且非常有前景的治疗靶点。

影响陈述

CKLF1 是一种最近发现的趋化因子，已被许多研究报告在相当多的疾病中发挥重要作用。然而，CKLF1 可能参与的潜在途径还没有很好地表现出来。在我们的综述中，我们展示了这种新型趋化因子的基本分子结构和主要功能，以及对人类疾病（如肿瘤）的影响。为了引起更多的关注，我们总结了它的信号通路，并在一组图中清楚地展示了它们。通过对CKLF1靶向药物在动物模型中的实验试验的概述，我们希望为医学研究人员和药学提供一些关于CKLF1的重要见解。