Background. Individuals with Parkinson’s Disease (PD) have bradykinesia during mobility tasks in the morning before intake of dopaminergic treatment and have difficulties managing Activities of Daily Living (ADLs). Early morning off (EMO) refers to off-states in the morning where the severity of bradykinesia is increased and causes a decrease in mobility related to wearing off of effects of medication. Measurements from devices capable of continuously recording motor symptoms may provide insight into the patient’s response to medication and possible impact on ADLs. Objectives. To test whether poor or slow response to medication in the morning predicts the overall ADL-level and to assess the association between change in bradykinesia score (BKS) and the risk of having disabilities within three selected ADL-items. Methods. In this cross-sectional study, the sample consists of 34 patients with light to moderate PD. Data collection encompasses measurements from the Parkinson KinetiGraph, and the ADL-limitations are assessed by the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part II. Results. The association between UPDRS- II and BKS from the algorithm was −0.082 (), 95% CL:−0.113; −0.042). The individuals experienced disabilities in performing “Speech” () and “Doing hobbies” () when being slow or poor responders to dopaminergic therapy. The PD patients’ L-dopa equivalent dose seems to be a strong predictor of the ADL-level in the morning. Conclusion. Slow response to the medication dosages in the morning is correlated with disabilities in the overall ADL-level in PD. The combination of PD-drugs and precise, timely dosages must be considered in the improvement of the ADL-level in PD patients.

中文翻译：

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“对晨间药物的反应能预测帕金森病当天的 ADL 水平吗？”

背景。帕金森病 (PD) 患者在早上接受多巴胺能治疗前的活动任务期间出现运动迟缓，并且难以管理日常生活活动 (ADL)。清晨休息 (EMO) 是指早上的休息状态，运动迟缓的严重程度增加并导致与药物效果消失相关的活动能力下降。能够连续记录运动症状的设备的测量结果可以深入了解患者对药物的反应以及对 ADL 的可能影响。目标. 测试早上对药物的不良反应或缓慢反应是否可以预测总体 ADL 水平，并评估运动迟缓评分 (BKS) 的变化与三个选定 ADL 项目中残疾风险之间的关联。方法。在这项横断面研究中，样本由 34 名轻至中度 PD 患者组成。数据收集包括来自 Parkinson KinetiGraph 的测量结果，ADL 限制由运动障碍协会统一帕金森病评定量表 (MDS-UPDRS) 第 II 部分评估。结果。算法中 UPDRS-II 和 BKS 之间的关联为 -0.082（), 95% CL:-0.113; -0.042)。个人在执行“演讲”时遇到了残疾（)和“做爱好” ()当对多巴胺能治疗反应缓慢或反应不佳时。PD 患者的左旋多巴当量剂量似乎是早晨 ADL 水平的强预测因子。结论。早上对药物剂量的反应迟缓与 PD 患者总体 ADL 水平的残疾有关。在改善 PD 患者的 ADL 水平时，必须考虑 PD 药物和精确、及时的剂量相结合。