ABSTRACT Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral diseases such as Ebola and HIV Hepatitis B and C. Using molecular modeling, this study evaluated the reactivity of ozone toward representative key molecules in the structure of SARS-CoV-2. The results show that ozone is able to attack the proteins and lipids of the virus’s spikes and envelope, particularly the amino acids tryptophan, methionine and cysteine, and the fatty acids, arachidonic acid, linoleic acid, and oleic acid. Ozone also attacks the N-glycopeptides of the spike protein subunits 1 and 2, though at lower reactivity. Disruption of the structure of SARS-CoV-2 could inactivate the virus, suggesting that ozone could be an effective oxidant against COVID-19 virus. If incorrectly applied, ozone is toxic and contact with the respiratory tract must be avoided.

中文翻译：

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臭氧：COVID-19 病毒 (SARS-CoV-2) 的潜在氧化剂

摘要 目前，尚无药物证明可有效治疗由 SARS-CoV-2 病毒引起的持续流行的 COVID-19。作为一种强氧化剂，臭氧对水中或表面和气溶胶中的大多数细菌和病毒具有致命性。臭氧还已成功用于治疗多种病毒性疾病，例如埃博拉病毒和 HIV 乙型和丙型肝炎。本研究使用分子模型评估了臭氧对 SARS-CoV-2 结构中代表性关键分子的反应性。结果表明，臭氧能够攻击病毒尖峰和包膜的蛋白质和脂质，尤其是氨基酸色氨酸、蛋氨酸和半胱氨酸，以及脂肪酸、花生四烯酸、亚油酸和油酸。臭氧还攻击刺突蛋白亚基 1 和 2 的 N-糖肽，但反应性较低。破坏 SARS-CoV-2 的结构可以使病毒失活，这表明臭氧可能是对抗 COVID-19 病毒的有效氧化剂。如果使用不当，臭氧是有毒的，必须避免与呼吸道接触。