Abstract

Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new benzopyranone with an uncommon carboxyl group at C-8, coniochaetone K (1), were obtained from the Beibu Gulf-derived coral symbiotic fungus Cladosporium halotolerans GXIMD 02502. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature values. The absolute configuration of 1 was accomplished by comparison of specific optical rotation as well as quantum chemical ECD calculations. The in vitro cytotoxicity of compounds 1–12 against two human prostatic cancer cell lines, C4-2B and 22RV1, were evaluated. And compounds 1, 3, 6–8, and 10–11 demonstrated significant cytotoxicity with inhibitions ranging from 55.8% to 82.1% at the concentration of 10 μM.

摘要

历史上已证明珊瑚衍生的微生物是生物活性次级代谢物的丰富来源。从北部湾衍生的珊瑚共生真菌Cladosporium halotolerans GXIMD 02502中获得了十二种苯并吡喃酮和/或呫吨酮衍生物，包括在 C-8 处具有罕见羧基的新苯并吡喃酮，coniochaetone K ( 1 )。光谱数据解释和与文献值的比较。的绝对构型1由比旋光度以及量子化学计算ECD的比较来实现的。在体外化合物的细胞毒性1 - 12评估了针对两种人前列腺癌细胞系 C4-2B 和 22RV1 的效果。和化合物1，3，6 - 8，和10 - 11证明显著细胞毒性的抑制在10浓度范围从55.8％至82.1％  μ M.