Enrofloxacin is a poorly soluble antibacterial drug of the fluoroquinolones class used in veterinary medicine. The main purpose of this work was to investigate the structural and pharmaceutical properties of new enrofloxacin salts. Enrofloxacin anhydrate and its organic salts with tartaric acid, nicotinic acid and suberic acid formed as pure crystalline anhydrous solids. All the crystals were grown from a mixed solution by slow evaporation at room temperature. These products were then characterized by field-emission scanning electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. Further, X-ray single crystal diffraction analysis was used to study the crystal structure. The intermolecular interactions and packing arrangements in the crystal structures were studied, and the solubility of these salts in water was determined using high-performance liquid chromatography. The results show that the new salts of enrofloxacin developed in this study exhibited excellent water solubility.

中文翻译：

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恩诺沙星与有机酸的药用盐

恩诺沙星是兽药中使用的氟喹诺酮类难溶性抗菌药。这项工作的主要目的是研究新的恩诺沙星盐的结构和药物性质。恩诺沙星无水物及其与酒石酸，烟酸和辛二酸的有机盐形成纯净的晶体无水固体。通过在室温下缓慢蒸发从混合溶液中生长所有晶体。然后通过场发射扫描电子显微镜，粉末X射线衍射，傅立叶变换红外光谱和差示扫描量热法对这些产品进行表征。此外，使用X射线单晶衍射分析来研究晶体结构。研究了晶体结构中的分子间相互作用和堆积排列，用高效液相色谱法测定这些盐在水中的溶解度。结果表明，在这项研究中开发的新的恩诺沙星盐表现出优异的水溶性。