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Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria.
Antibiotics ( IF 4.8 ) Pub Date : 2020-07-27 , DOI: 10.3390/antibiotics9080450
Suresh Mickymaray 1 , Faiz Abdulaziz Alfaiz 1 , Anand Paramasivam 2
Affiliation  

Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

中文翻译:

黄酮类化合物对新兴机会性非结核分枝杆菌的功效和机制。

非结核分枝杆菌(NTM)是严重的慢性肺部疾病的病原体,并负责创伤后伤口感染,淋巴结炎,子宫内膜炎,皮肤,眼睛感染和传播性疾病。由于包括传统的和现有的抗结核药在内的多药耐药性,这些感染的治疗极具挑战性。因此,当前的研究旨在评估类黄酮对NTM的抗分枝杆菌活性,它们与药理剂的协同作用以及其阻断毒力的能力。类黄酮单独或以协同组合的形式具有潜在的抗分枝杆菌作用。与现有抗分枝杆菌药一起使用的类黄酮混合物是减轻副作用的一种策略。
更新日期:2020-07-27
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