Microbial natural products underpin the majority of antimicrobial compounds in clinical use and the discovery of new effective antibacterial treatments is urgently required to combat growing antimicrobial resistance. Non-ribosomal peptides are a major class of natural products to which many notable antibiotics belong. Recently, a new family of non-ribosomal peptide antibiotics were discovered—the desotamide family. The desotamide family consists of desotamide, wollamide, surugamide, ulleungmycin and noursamycin/curacomycin, which are cyclic peptides ranging in size between six and ten amino acids in length. Their biosynthesis has attracted significant attention because their highly functionalised scaffolds are cyclised by a recently identified standalone cyclase. Here, we provide a concise review of the desotamide family of antibiotics with an emphasis on their biosynthesis.

中文翻译：

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Desotamide抗生素家族。

微生物天然产物是临床使用中大多数抗菌化合物的基础，迫切需要发现新的有效抗菌疗法来对抗不断增长的抗菌素耐药性。非核糖体肽是许多著名抗生素所属的天然产物的主要类别。最近，发现了一个新的非核糖体肽抗生素家族-去氨酰胺家族。脱氨酰胺家族由脱氨酰胺，wollamide，surugamide，ulleungmycin和noursamycin / curacomycin组成，它们是环状肽，长度在6至10个氨基酸之间。它们的生物合成引起了极大的关注，因为其高度功能化的支架被最近鉴定的独立环化酶环化了。这里，