A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1-O-phosphono moiety and three different substituents at C-2 has been prepared. Due to the structural similarities of these scaffolds to the native substrate of mycobacterial galactofuranosyltransferase GlfT2 in the transition state, we evaluated these compounds by computational methods, as well as in an enzyme assay for the possible inhibition of the mycobacterial galactan biosynthesis. Our data show that despite favorable docking scores to the active site of GlfT2, none of these compounds serve as efficient inhibitors of the enzymes involved in the mycobacterial galactan biosynthesis.

中文翻译：

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β-果糖呋喃糖基和β-呋喃呋喃糖基砜的合成，对接研究和生物学评估，它们是针对半乳糖呋喃糖基转移酶GlfT2的分枝杆菌半乳聚糖合成的潜在抑制剂。

已经制备了一系列十个新颖的在1-C上带有1- O-膦酰基部分和三个不同取代基的β-果糖呋喃糖基和β-呋喃呋喃糖基砜。由于这些支架与分枝状态的分枝杆菌半乳糖呋喃糖基转移酶GlfT2的天然底物在结构上具有相似性，因此我们通过计算方法以及酶法评估了这些化合物对分枝杆菌半乳聚糖生物合成的可能抑制作用。我们的数据表明，尽管对GlfT2的活性位点有良好的对接分数，但这些化合物均不能用作分枝杆菌半乳聚糖生物合成中所涉及酶的有效抑制剂。