Evidence suggests that amyloid β (Aβ) peptides play an important role in the degeneration of neurons during the development of Alzheimer's disease (AD), the prevalent cause of dementia affecting the elderly. The endosomal–lysosomal system, which acts as a major site for Aβ metabolism, has been shown to exhibit abnormalities in vulnerable neurons of the AD brain, reflected by enhanced levels/expression of lysosomal enzymes including cathepsin D (CatD). At present, the implication of CatD in selective neuronal vulnerability in AD pathology remains unclear.

中文翻译：

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细胞溶质组织蛋白酶 D 在阿尔茨海默病病理学中的意义：PLGA 纳米颗粒对 β-淀粉样蛋白毒性的保护性细胞作用

有证据表明，淀粉样蛋白 β (Aβ) 肽在阿尔茨海默病 (AD) 发展过程中的神经元退化中起重要作用，阿尔茨海默病是影响老年人的痴呆症的常见原因。内体-溶酶体系统是 Aβ 代谢的主要场所，已被证明在 AD 大脑的脆弱神经元中表现出异常，这反映在溶酶体酶（包括组织蛋白酶 D（CatD））的水平/表达增强。目前，CatD 在 AD 病理学中选择性神经元易损性中的意义尚不清楚。