Gardenia jasminoides, a kind of flowering plant, possesses numerous bio‐activities. The purpose of this study was to investigate the characteristics and hypoglycemic effects of fermented milk (CFM, GFM_1, GFM_2,and GFM₃) contained with 0, 0.1%, 0.2%, and 0.3% of G. jasminoides water extracts. We demonstrated that GFM₃ has the highest total count of lactic acid bacteria, water‐holding capacity, and antioxidant activities (DPPH, ABTS, and FRAP) among four kinds of fermented milk. In vivo hypoglycemic activity showed that GFM₃ notably reduced blood glucose levels, insulin, weight loss rate, food intake, and organ indexes compared with model group. GFM₃ could improve the diabetes by reducing the levels of serum TC, TG, LDL‐C, and increasing HDL‐C content (p < .01). Moreover, it can also increase the levels of hepatic T‐SOD, GSH‐Px, CAT, hexokinase, and glycogen and decrease MDA content in liver (p < .05 or p < .01). Furthermore, GFM₃ stimulated the phosphorylations of p‐adenosine 5′‐monophosphate‐activated protein kinase (AMPK) and Acetyl‐CoA carboxylase (ACC), but an inhibitor of Fatty acid synthase (FAS), p < .01. Overall, GFM₃ treatment protected the mice better than CFM, so Gardenia jasminoides water extracts is expected to become a hypoglycemic agent.

中文翻译：

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Garden子茉莉水提取物所含发酵乳对链脲佐菌素诱导的小鼠的抗糖尿病作用

子，一种开花植物，具有多种生物活性。这项研究的目的是调查含有0、0.1 ％，0.2％和0.3％的茉莉花茶水提取物的发酵乳（CFM，GFM _1， GFM ₂和GFM ₃）的特性和降血糖作用。我们证明，GFM ₃在四种发酵乳中具有最高的乳酸菌总数，保水能力和抗氧化活性（DPPH，ABTS和FRAP）。体内降血糖活性表明GFM ₃与模型组相比，血糖，胰岛素，减肥率，食物摄入和器官指标显着降低。GFM ₃可以通过降低血清TC，TG，LDL-C和增加HDL-C含量来改善糖尿病（p  <.01）。此外，它还可以增加肝脏T-SOD，GSH-Px，CAT，己糖激酶和糖原的水平，并降低肝脏中的MDA含量（p  <.05或p  <.01）。此外，GFM ₃刺激了对腺苷5'-单磷酸激活的蛋白激酶（AMPK）和乙酰辅酶A羧化酶（ACC）的磷酸化，但是脂肪酸合酶（FAS）的抑制剂，p  <.01。总体而言，GFM ₃处理对小鼠的保护作用优于CFM，因此子茉莉水提取物有望成为降糖药。