Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single‐stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular biology by inhibiting the translation process; it is demonstrated that any alteration in their sequence especially single‐nucleotide polymorphisms (SNPs) may lead into increasing the breast cancer risk. miR‐SNPs are considered to be the potential biomarkers for early detection of breast cancer. As a result, this review documents the well‐known miR‐SNPs that are known to be associated with breast cancer. In this regard, two principals were discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.

中文翻译：

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microRNA 相关的单核苷酸多态性和乳腺癌。

乳腺癌作为女性最常见的癌症，对患者的精神和身体都有影响，需要在许多领域和多个层面给予高度关注，因为众所周知，这种癌症是多因素的。具有近 22 个核苷酸的称为 microRNA 的单链分子被认为通过抑制翻译过程在分子生物学的中心法则中起作用；已经证明，它们序列的任何改变，尤其是单核苷酸多态性 (SNP) 都可能导致乳腺癌风险增加。miR-SNPs被认为是乳腺癌早期检测的潜在生物标志物。因此，本综述记录了已知与乳腺癌相关的众所周知的 miR-SNP。在这方面，讨论了两个主要负责人：(a) microRNAs 靶基因中的 S​​NPs 以及由于这种现象导致的基因表达改变；(b) 基于 microRNA 编码区 SNP 的变化以及它们与目标信使 RNA 相互作用的影响。