Probe goes viral. The SARS‐CoV‐2 main protease is an attractive drug target to combat the causative agent of covid19. We report activity‐based probes of this protease that are selective even in the presence of a human proteome. These reagents will allow detection of the M^pro as well as verification of target engagement by antiviral drugs against SARS‐CoV‐2.

中文翻译：

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肽基酰氧基甲基酮是SARS-CoV-2主要蛋白酶的基于活性的探针。

探针会传播病毒。SARS-CoV-2主要蛋白酶是对抗covid19病原体的诱人药物靶标。我们报告了这种蛋白酶的基于活性的探针，即使在存在人类蛋白质组的情况下也具有选择性。这些试剂可以检测M ^pro并验证抗SARS-CoV-2抗病毒药物对靶标的参与。