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Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis
Neurobiology of Stress ( IF 5 ) Pub Date : 2020-07-27 , DOI: 10.1016/j.ynstr.2020.100244
Lil Meyer-Arndt 1 , Stefan Hetzer 2 , Susanna Asseyer 1 , Judith Bellmann-Strobl 1, 3 , Michael Scheel 1 , Jan-Patrick Stellmann 4, 5, 6 , Christoph Heesen 4 , Andreas K Engel 7 , Alexander U Brandt 1, 8 , John-Dylan Haynes 1, 2, 9 , Friedemann Paul 1, 3, 10 , Stefan M Gold 4, 11, 12 , Martin Weygandt 1, 2
Affiliation  

Background

Multiple sclerosis (MS) is characterized by two neuropathological key aspects: inflammation and neurodegeneration. Clinical studies support a prospective link between psychological stress and subsequent inflammatory disease activity. However, it is unknown if a similar link exists for grey matter (GM) degeneration as the key driver of irreversible disability.

Methods

We tested whether neural network activity triggered in a psychological fMRI stress paradigm (a mental arithmetic task including social evaluation) conducted at a baseline time point predicts future GM atrophy in 25 persons with MS (14 females). Atrophy was determined between the baseline and a follow-up time point with a median delay of 1012 (Rg: 717–1439) days. Additionally, atrophy was assessed in 22 healthy subjects (13 females; median delay 771 [Rg: 740–908] days between baseline and follow-up) for comparison.

Results

An analysis of longitudinal atrophy in patients revealed GM loss in frontal, parietal, and cerebellar areas. Cerebellar atrophy was more pronounced in patients than controls. Future parietal and cerebellar atrophy could be predicted based on activity of two networks. Perceived psychological stress was negatively related to future parietal atrophy in patients and activity of the network predictive of parietal atrophy was positively linked to perceived stress.

Conclusions

We have shown that blunted neural and psychological stress processing have a detrimental effect on the course of MS and are interrelated. Together with research showing that psychological and neural stress processing can be altered through interventions, our findings suggest that stress processing might constitute an important modifiable disease factor.



中文翻译:

迟钝的神经和心理压力处理可预测多发性硬化症中未来的灰质萎缩

背景

多发性硬化症 (MS) 的特征在于两个神经病理学关键方面:炎症和神经变性。临床研究支持心理压力与随后的炎症性疾病活动之间的前瞻性联系。然而,尚不清楚灰质 (GM) 退化是否存在类似的联系作为不可逆残疾的关键驱动因素。

方法

我们测试了在基线时间点进行的心理 fMRI 压力范式(包括社会评估的心算任务)中触发的神经网络活动是否可以预测 25 名 MS 患者(14 名女性)未来的 GM 萎缩。在基线和随访时间点之间确定萎缩,中位延迟为 1012 (Rg: 717-1439) 天。此外,对 22 名健康受试者(13 名女性;基线和随访之间的中位延迟 771 [Rg: 740-908] 天)进行了萎缩评估以进行比较。

结果

对患者纵向萎缩的分析显示额叶、顶叶和小脑区域的 GM 损失。患者的小脑萎缩比对照组更明显。可以根据两个网络的活动来预测未来的顶叶和小脑萎缩。感知到的心理压力与患者未来的顶叶萎缩呈负相关,预测顶叶萎缩的网络活动与感知压力呈正相关。

结论

我们已经证明,迟钝的神经和心理压力处理对 MS 的病程有不利影响,并且是相互关联的。连同研究表明可以通过干预改变心理和神经压力处理,我们的研究结果表明,压力处理可能构成一个重要的可改变的疾病因素。

更新日期:2020-07-27
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