Mulberry leaves and white kidney beans may improve postprandial glycaemic control. However, data are lacking on the combined anti-diabetic effect of these two plant extracts among pre-diabetic individuals. This randomized controlled study aimed to evaluate the acute and chronic effects of mulberry leaf and white kidney bean extract mix (MWEM) on postprandial glycaemic control in 66 pre-diabetic subjects. In the acute effect test, ingestion of MWEM led to a significant decrease in the postprandial glucose, insulin, and C-peptide, as well as the incremental area under the curves from 0 to 120 min (iAUCs_0–120min) for glucose, insulin, and C-peptide. In the chronic effect test, no significant treatment × time interactions were observed in the iAUCs_0–120min, as well as the homeostatic model assessment-insulin resistance (HOMA-IR), haemoglobin A1c (HbA1c), and glycated serum protein (GSP) levels. The consumption of MWEM with a meal could potentially help to improve postprandial glycaemic control in pre-diabetic individuals.

桑叶和白芸豆可以改善餐后血糖控制。然而，缺乏关于前糖尿病个体中这两种植物提取物的组合抗糖尿病作用的数据。这项随机对照研究旨在评估66名糖尿病前期受试者桑叶和白芸豆提取物混合物（MWEM）对餐后血糖控制的急性和慢性作用。在急性效果试验，MWEM的摄取导致餐后血糖，胰岛素曲线下一个显著降低，C-肽，以及增量区域从0到120分钟（iAUCs _0-120min）葡萄糖，胰岛素和C肽。在慢性效应试验中，在iAUC _{0–120min内未}观察到明显的治疗×时间相互作用，以及稳态模型评估-胰岛素抵抗（HOMA-IR），血红蛋白A1c（HbA1c）和糖化血清蛋白（GSP）的水平。随餐服用MWEM可能有助于改善糖尿病前个体的餐后血糖控制。