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Channel and Motor Proteins for Translocation of Nucleic Acids in Nanopore Sequencing
Moscow University Chemistry Bulletin Pub Date : 2020-07-27 , DOI: 10.3103/s0027131420030025
D. V. Barkova , M. S. Andrianova , N. V. Komarova , A. E. Kuznetsov

Abstract

The channel proteins used in nanopore sequencing, their modifications, and auxiliary proteins regulating the process of nucleic acid translocation are considered. In the process of nanopore sequencing, the primary structure of the test DNA or RNA is decrypted by the translocation of a nucleic acid molecule through a nanopore intercalated into the membrane. A nanopore is a protein transmembrane channel that is permeable to water, low-molecular-weight ions, and single-stranded DNA or RNA.


中文翻译:

纳米孔测序中核酸易位的通道和运动蛋白

摘要

考虑了纳米孔测序中使用的通道蛋白,它们的修饰以及调节核酸转运过程的辅助蛋白。在纳米孔测序的过程中,待测DNA或RNA的一级结构通过核酸分子通过插入膜中的纳米孔的移位而被解密。纳米孔是蛋白质跨膜通道,可透过水,低分子量离子和单链DNA或RNA。
更新日期:2020-07-27
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